Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

Tongde Wu, Fei Zhao, Beixue Gao, +7

Genes & Development

Nrf2-mediated Cellular ProtectionLipid PeroxidationPathologyEr StressReactive Oxygen Species +18

USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development

Zhenghong Lin, Hee‐Young Yang, Qingfei Kong, +8

Molecular Cell

Transcriptional RegulationDevelopmental BiologySignaling PathwayCell RegulationApoptosis +10

The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

Jinping Zhang, Sang‐Myeong Lee, Stephen Shannon, +8

Journal of Clinical Investigation

Histone ModificationsSirt1 FunctionEpigenetic ChangeT-regulatory CellImmunology +18

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

Shengyi Sun, Guojun Shi, Haibo Sha, +23

Nature Cell Biology

Endogenous SubstrateSignal TransductionEndoplasmic Reticulum BiologySecretory PathwayCell Biology +6

USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation

Zhenghong Lin, Hee‐Young Yang, Can Tan, +7

Cell Reports

Tumor BiologyTranscriptional RegulationCell RegulationMedicineImmunology +12

Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes

S.-M. Lee, Hee‐Young Yang, Danielle Tartar, +5

Diabetologia

ObesityMetabolic SyndromeType 1Diabetes ManagementMedicine +10

RLE-1, an E3 Ubiquitin Ligase, Regulates C. elegans Aging by Catalyzing DAF-16 Polyubiquitination

Wensheng Li, Beixue Gao, Sang‐Myeong Lee, +2

Developmental Cell

Systems BiologySignaling PathwayE3 Ubiquitin LigaseCell RegulationMolecular Regulation +8

Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen‐induced arthritis

Beixue Gao, Sang‐Myeong Lee, An Chen, +5

EMBO Reports

InflammationRheumatologyMusculoskeletal ResearchImmunologyIre1 Ubiquitination +12

FoxP3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1

Sang‐Myeong Lee, Beixue Gao, Deyu Fang

Blood

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism

Johanna Melo‐Cardenas, Yuanming Xu, Juncheng Wei, +10

Blood