ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al. · Cell · 2012 · 17K citations · Full text

Iron Deficiency, Nonapoptotic Cell Death, Metalloprotein +9

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang, Rohitha Sriramaratnam, Matthew Welsch et al. · Cell · 2014 · 7.1K citations · Full text

Tumor Biology, Medicine, Apoptosis +5

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll, Bettina Proneth, Yulia Y. Tyurina et al. · Nature Chemical Biology · 2016 · 3.8K citations · Full text

Proteinlipid Interaction, Biochemistry, Natural Sciences +4

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Kirill Bersuker, Joseph M. Hendricks, Zhipeng Li et al. · Nature · 2019 · 3.4K citations · Full text

Aldo-keto Reductase, Biochemistry, Natural Sciences +10

FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll, Florêncio Porto Freitas, Ron Shah et al. · Nature · 2019 · 3K citations · Full text

Redox Signaling, Signal Transduction, Biochemistry +7