Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

Shannon L. Maude, Noelle V. Frey, Pamela A. Shaw et al. · New England Journal of Medicine · 2014 · 5.4K citations · Full text

Life Sciences, Hematology, Immunology +17

<i>LMO2</i> -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

S. Hacein-Bey-Abina, Christof von Kalle, Manfred Schmidt et al. · Science · 2003 · 3.6K citations

Life Sciences, Genetics, Immunology +17

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

Simon Forbes, Nidhi Bindal, Sally Bamford et al. · Nucleic Acids Research · 2010 · 2.3K citations · Full text

Medicine, Genetics, Oncology +17

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

Salima Hacein‐Bey‐Abina, Alexandrine Garrigue, Gary P. Wang et al. · Journal of Clinical Investigation · 2008 · 1.8K citations · Full text

Medicine, Molecular Genetics, Oncology +14

HIV-1 Integration in the Human Genome Favors Active Genes and Local Hotspots

A. R. W. Schröder, Paul Shinn, Huaming Chen et al. · Cell · 2002 · 1.8K citations · Full text

Life Sciences, Genetics, Molecular Genetics +12