CRISPR-engineered T cells in patients with refractory cancer

Edward A. Stadtmauer, Joseph A. Fraietta, Megan M. Davis, +38

Science

Human β-defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2

Nicholas Funderburg, Michael M. Lederman, Zhimin Feng, +5

Proceedings of the National Academy of Sciences

Adaptive Immune SystemInnate Immune SystemImmunologyImmunologic MechanismHuman Tlr Signaling +16

Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results

Stephen Bagley, Meghan Logun, Joseph A. Fraietta, +30

Nature Medicine

Cancer ImmunosurveillanceGliomaImmunologyTrial Interim ResultsImmune Checkpoint Inhibitor +7

Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients

Katherine T. Marcucci, Julie K. Jadlowsky, Wei‐Ting Hwang, +10

Molecular Therapy

BLIMP1 and NR4A3 transcription factors reciprocally regulate antitumor CAR T cell stemness and exhaustion

In-Young Jung, Vivek Narayan, Sierra McDonald, +16

Science Translational Medicine

Negative Elongation Factor Is Required for the Maintenance of Proviral Latency but Does Not Induce Promoter-Proximal Pausing of RNA Polymerase II on the HIV Long Terminal Repeat

Julie K. Jadlowsky, Julian Y. Wong, Amy C. Graham, +5

Molecular and Cellular Biology

Viral ReplicationRna Polymerase IiImmunologyMolecular BiologyTranscriptional Regulation +19

CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication

Pablo Tebas, Julie K. Jadlowsky, Pamela A. Shaw, +23

Journal of Clinical Investigation

ImmunodeficienciesImmunologyCd4 T Cell ResponsesT CellsCcr5 δ32 +15

BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia

Weimin Kong, Alexander J. Dimitri, Wang Wenliang, +30

Journal of Clinical Investigation

Chronic Lymphocytic LeukemiaT-regulatory CellImmunologyImmunoeditingPathology +14

The Toll-like receptor 1/2 agonists Pam3CSK4 and human β-defensin-3 differentially induce interleukin-10 and nuclear factor-κB signalling patterns in human monocytes

Nicholas Funderburg, Julie K. Jadlowsky, Michael M. Lederman, +3

Immunology

Two cases of severe pulmonary toxicity from highly active mesothelin-directed CAR T cells

Andrew R. Haas, Ryan Golden, Leslie A. Litzky, +30

Molecular Therapy

AllergyLung InflammationRespiratory ToxicologyImmunologyPulmonary Pharmacology +5