Concepedia

Cardiomyocyte-derived USP28 negatively regulates antioxidant response and promotes cardiac hypertrophy via deubiquitinating TRIM21

Jibo Han, Liming Lin, Zimin Fang, Bozhi Ye, Xue Han, Jiachen Xu, Julian Min, Jinfu Qian, Gaojun Wu, Yi Wang,

Theranostics · 2024 · 22 citations · 15 references

DOIFull text

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Concepts

Abstract

Our study illustrates a cardiomyocyte-specific USP28-TRIM21 axis in regulating hypertrophic cardiomyopathy and presents USP28 as a potential target for the treatment of cardiac hypertrophy.

References

15

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis

Ji-An Pan, Yu Sun, Ya-Ping Jiang et al. · Molecular Cell · 2016 · 258 citations · Full text

, , +14

The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer

Markus E. Diefenbacher, Nikita Popov, Sophia M. Blake et al. · Journal of Clinical Investigation · 2014 · 155 citations · Full text

, , +17

Distinct Phenotypes Induced by Three Degrees of Transverse Aortic Constriction in Mice

Daniel A. Richards, Mark Aronovitz, Timothy D. Calamaras et al. · Scientific Reports · 2019 · 141 citations · Full text

, , +16

Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

Kai Hou, Jianliang Shen, Junrong Yan et al. · EBioMedicine · 2021 · 138 citations · Full text

, , +17

USP25 Ameliorates Pathological Cardiac Hypertrophy by Stabilizing SERCA2a in Cardiomyocytes

Bozhi Ye, Hao Zhou, Yanghao Chen et al. · Circulation Research · 2023 · 120 citations · Full text

, , +12