Autophagy mediates degradation of nuclear lamina

Zhixun Dou, Caiyue Xu, Greg Donahue, +17

Nature

Cell AutophagyNuclear LaminaAutophagyProtein DegradationLipophagy +2

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis

Ji-An Pan, Yu Sun, Ya-Ping Jiang, +13

Molecular Cell

Redox SignalingRedox RegulatorGeneticsSuppresses Protein SequestrationRedox Homeostasis +6

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism

Alex J. Bott, Jianliang Shen, Claudia Tonelli, +26

Cell Reports

Class IA PI3K p110β Subunit Promotes Autophagy through Rab5 Small GTPase in Response to Growth Factor Limitation

Zhixun Dou, Ji-An Pan, Hashem A. Dbouk, +9

Molecular Cell

Cell AutophagyMitophagySignal TransductionSignaling PathwayCell Regulation +8

Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

Kai Hou, Jianliang Shen, Junrong Yan, +10

EBioMedicine

The class IA phosphatidylinositol 3-kinase p110-β subunit is a positive regulator of autophagy

Zhixun Dou, Mohar Chattopadhyay, Ji-An Pan, +6

The Journal of Cell Biology

Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4

Joseph M. Catanzaro, Namratha Sheshadri, Ji-An Pan, +6

Nature Communications

Cancer ImmunosurveillanceOncogenic RasSquamous Cell CarcinomaOncogenic AgentImmunology +4

SCCA1/SERPINB3 Promotes Oncogenesis and Epithelial–Mesenchymal Transition via the Unfolded Protein Response and IL6 Signaling

Namratha Sheshadri, Joseph M. Catanzaro, Alex J. Bott, +8

Cancer Research

Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2′-O-methyltransferase activity of nsp10/nsp16 complex

Min Ke, Yu Chen, Andong Wu, +8

Virus Research

Virus StructureMedicineViral PathogenesisNsp10/nsp16 ComplexMolecular Biology +6