Concepedia

Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions

Yujun Hou, Xixia Chu, Jae Hyeon Park, Qing Zhu, Mansoor Hussain, Zhiquan Li, Helena Borland Madsen, Beimeng Yang, Yong Wei, Yue Wang,

Alzheimer s & Dementia · 2024 · 72 citations · 65 references

DOIFull text

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Abstract

Long-term urolithin A (UA) treatment improved learning, memory, and olfactory function in Alzheimer's disease (AD) mice. UA restored lysosomal functions in part by regulating cathepsin Z (Ctsz) protein. UA modulates immune responses and AD-specific pathophysiological pathways.

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Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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2022 Alzheimer's disease facts and figures

Alzheimer s & Dementia · 2022 · 2.3K citations

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Bin Zhang, Chris Gaiteri, Liviu‐Gabriel Bodea et al. · Cell · 2013 · 1.7K citations · Full text

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