The role of TGF-β signaling in muscle atrophy, sarcopenia and cancer cachexia

Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member

Alexandra C. McPherron, Ann M. Lawler, Se‐Jin Lee · Nature · 1997 · 3.9K citations

Mechanobiology, Muscle Function, Molecular Physiology +11

Identification and characterization of a spinal muscular atrophy-determining gene

Suzie Lefebvre, Lydie Bürglen, Sophie Reboullet et al. · Cell · 1995 · 3.9K citations · Full text

Genetics, Gene Characterization, Molecular Genetics +3

Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

Marco Sandri, Claudia Sandri, Alex Gilbert et al. · Cell · 2004 · 2.9K citations · Full text

Transcriptional Regulation, Skeletal Muscle, Genetics +6

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

Sue C. Bodine, Trevor N. Stitt, Michael Gonzalez et al. · Nature Cell Biology · 2001 · 2.7K citations

Skeletal Muscle Hypertrophy, Molecular Physiology, Muscle Injury +10

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

Kenneth L. Rock, Colette F. Gramm, Lisa Rothstein et al. · Cell · 1994 · 2.5K citations

Proteasome Block, Biochemistry, Mhc Class +13