Concepedia

Cancer-associated fibroblasts reprogram cysteine metabolism to increase tumor resistance to ferroptosis in pancreatic cancer

Yuchao Zhu, Shuai Fang, Bolin Fan, Kaiwei Xu, Xu Liu, Linwei Wang, Lubin Zhu, Chunqu Chen, Ruoyu Wu, Jiajing Ni,

Theranostics · 2024 · 67 citations · 19 references

DOIFull text

Open access

Concepts

Abstract

Taken together, the findings demonstrate a novel metabolic relationship between CAFs and cancer cells, in which cysteine generated by CAFs acts as a substrate in the prevention of oxidative damage in PDAC and thus suggests new therapeutic targets for PDAC.

References

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