Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

Neta Erez, Morgan Truitt, Peter Olson, +1

Cancer Cell

InflammationTumor BiologyNf-κb-dependent MannerMedicineImmune Regulation +9

NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

Nour Ershaid, Yoray Sharon, Hila Doron, +12

Nature Communications

Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1

Noam Cohen, Ophir Shani, Yael Raz, +4

Oncogene

Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer

Yael Raz, Noam Cohen, Ophir Shani, +9

The Journal of Experimental Medicine

Breast OncologyBiological MicroenvironmentsPdgfrα-expressing CafsPathologyCancer Biology +15

Plasticity in Tumor-Promoting Inflammation: Impairment of Macrophage Recruitment Evokes a Compensatory Neutrophil Response

Jessica Pahler, Simon Tazzyman, Neta Erez, +5

Neoplasia

Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators

João Conniot, Anna Scomparin, Carina Peres, +13

Nature Nanotechnology

Checkpoint ModulatorsNanomedicineMannosylated NanovaccinesCancer ImmunosurveillanceMelanoma +9

Melanoma miRNA trafficking controls tumour primary niche formation

Shani Dror, Laureen Sander, Hila Schwartz, +22

Nature Cell Biology

Tumor BiologyMedicineMelanomaMelanoma Mirna TraffickingMicrorna Detection +4

Activated p53 suppresses the histone methyltransferase EZH2 gene

Xiaohu Tang, Michael Milyavsky, Igor Shats, +3

Oncogene

Histone ModificationsChromatinChromatin RemodelingEpigenetic ChangeEpigenomics +4

Tumor-Derived Osteopontin Reprograms Normal Mammary Fibroblasts to Promote Inflammation and Tumor Growth in Breast Cancer

Yoray Sharon, Yael Raz, Noam Cohen, +4

Cancer Research

Breast OncologyCancer BiologyOsteoporosisTumor BiologyBone Morphogenic Protein +15

Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors

Neta Erez, Sarah Glanz, Yael Raz, +2

Biochemical and Biophysical Research Communications

Human BreastPro-inflammatory FactorsBreast OncologyMedicineCancer Associated Fibroblasts +7