Concepedia

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Cristovão M. Sousa, Douglas E. Biancur, Xiaoxu Wang, Christopher J. Halbrook, Mara H. Sherman, Li Zhang, Daniel M. Kremer, Rosa F. Hwang, Agnes K. Witkiewicz, Haoqiang Ying,

Nature · 2016 · 1.1K citations · 23 references

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23

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

Kenneth P. Olive, Michael A. Jacobetz, Christian J. Davidson et al. · Science · 2009 · 3.1K citations · Full text

, , +17

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Berna C. Özdemir, Tsvetelina Pentcheva‐Hoang, Julienne L. Carstens et al. · Cancer Cell · 2014 · 2.6K citations

, , +15

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

Haoqiang Ying, Alec C. Kimmelman, Costas A. Lyssiotis et al. · Cell · 2012 · 2K citations · Full text

, , +11

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer

Christine Feig, James O. Jones, Matthew Kraman et al. · Proceedings of the National Academy of Sciences · 2013 · 2K citations

, , +17

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

Andrew D. Rhim, Paul E. Oberstein, Dafydd Thomas et al. · Cancer Cell · 2014 · 2K citations · Full text

, , +13