Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

Mara H. Sherman, Ruth T. Yu, Dannielle D. Engle, +25

Cell

Tumor BiologyPancreatic CancerMedicinePharmacologyGastroenterology +4

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Cristovão M. Sousa, Douglas E. Biancur, Xiaoxu Wang, +12

Nature

Cell AutophagyAutophagic Alanine SecretionPancreatic CancerMedicineAutophagy +6

A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

Ning Ding, Ruth T. Yu, Nanthakumar Subramaniam, +14

Cell

FibrosisSignal TransductionHepatologyLiver PhysiologyImmunology +11

A Stromal Lysolipid–Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression

Francesca R. Auciello, Vinay Bulusu, Chet Oon, +19

Cancer Discovery

Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

Gregor Werba, Daniel Weissinger, Emily Kawaler, +20

Nature Communications

BRD4 is a novel therapeutic target for liver fibrosis

Ning Ding, Nasun Hah, Ruth T. Yu, +7

Proceedings of the National Academy of Sciences

Liver FibrosisImmunologyPathologyExtracellular Matrix ComponentsInflammation +16

Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours

Ziwen Zhu, Abhinav Achreja, Noah Meurs, +17

Nature Metabolism

Tumor BiologyOncogenic AgentKetoacid DependencyMedicineStromal-rich Pdac Tumours +6

Stromal cues regulate the pancreatic cancer epigenome and metabolome

Mara H. Sherman, Ruth T. Yu, Tiffany Tseng, +13

Proceedings of the National Academy of Sciences

AID-Induced Genotoxic Stress Promotes B Cell Differentiation in the Germinal Center via ATM and LKB1 Signaling

Mara H. Sherman, Ali Kuraishy, Chetan Deshpande, +7

Molecular Cell

Developmental BiologySignaling PathwayCell DivisionCell RegulationCell Interaction +9

Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia

Shih‐Shih Chen, Aparna Raval, Amy J. Johnson, +18

Proceedings of the National Academy of Sciences

Disease ProgressionMixed-phenotype Acute LeukemiaGeneticsDna MethylationImmunology +19