Overview of the development of protein arginine methyltransferase modulators: Achievements and future directions

<i>MTAP</i> deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

Gregory V. Kryukov, Frederick H. Wilson, Jason R. Ruth et al. · Science · 2016 · 653 citations

Medicine, Cancer Biology, Oncology +17

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Elayne Chan-Penebre, Kristy G. Kuplast, Christina R. Majer et al. · Nature Chemical Biology · 2015 · 546 citations

Medicine, Medicinal Chemistry, Pharmacology +8

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

Ernesto Guccione, C. Bassi, Fabio Casadio et al. · Nature · 2007 · 489 citations

Life Sciences, Genetics, Molecular Biology +12

Crystal structure of the human PRMT5:MEP50 complex

Stephen Antonysamy, Zahid Bonday, Robert M. Campbell et al. · Proceedings of the National Academy of Sciences · 2012 · 363 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss

Andrew Fedoriw, Satyajit Rajapurkar, Shane W. O’Brien et al. · Cancer Cell · 2019 · 347 citations · Full text

Medicine, Oncology, Pharmacology +7