Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

Ann‐Lii Cheng, Yoon‐Koo Kang, Zhendong Chen et al. · The Lancet Oncology · 2008 · 5.8K citations

Hepatology, Medicine, Cancer Management +12

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll, Bettina Proneth, Yulia Y. Tyurina et al. · Nature Chemical Biology · 2016 · 3.8K citations · Full text

Proteinlipid Interaction, Biochemistry, Natural Sciences +4

Ferroptosis as a p53-mediated activity during tumour suppression

Le Jiang, Ning Kon, Tongyuan Li et al. · Nature · 2015 · 3.2K citations · Full text

Cancer Research, Medicine, Pathology +9

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan, Gaowei Mao, Feng Qu et al. · Nature Chemical Biology · 2016 · 2.7K citations · Full text

Adrenal Gland, Oxysterol, Biochemistry +9

Role of Mitochondria in Ferroptosis

Minghui Gao, Jun-Mei Yi, Jiajun Zhu et al. · Molecular Cell · 2018 · 2K citations · Full text

Mitochondrial Function, Biochemistry, Mitochondrial Dynamic +9