Role of Mitochondria in Ferroptosis

Minghui Gao, Jun-Mei Yi, Jiajun Zhu, +4

Molecular Cell

Mitochondrial FunctionBiochemistryMitochondrial DynamicMitochondrial StructureMitochondrial Biology +7

Cytoplasmic chromatin triggers inflammation in senescence and cancer

Zhixun Dou, Kanad Ghosh, Maria Grazia Vizioli, +21

Nature

ChromatinChromatin RemodelingMedicineCellular SenescenceCell Biology +3

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

Jun-Mei Yi, Jiajun Zhu, Jiao Wu, +2

Proceedings of the National Academy of Sciences

Autophagy mediates degradation of nuclear lamina

Zhixun Dou, Caiyue Xu, Greg Donahue, +17

Nature

Cell AutophagyNuclear LaminaAutophagyProtein DegradationLipophagy +2

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

Jiajun Zhu, Morgan A. Sammons, Greg Donahue, +11

Nature

Cancer ResearchChromatinChromatin RemodelingMedicineCancer Growth +8

Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation

Jiajun Zhu, Mirela Berisa, Simon Schwörer, +3

Cell Metabolism

BiochemistryCell TraffickingExtracellular Cysteine LimitationCell CultureCell Proliferation +6

Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α

Lijian Wu, Yiteng Jin, Xi Zhao, +9

Cell Metabolism

Immune EvasionCancer ImmunosurveillanceImmunologyTumor ImmunityImmune Regulation +9

Proline biosynthesis is a vent for TGFβ‐induced mitochondrial redox stress

Simon Schwörer, Mirela Berisa, Sara Violante, +5

The EMBO Journal

Redox SignalingBiochemistryMitochondrial FunctionMitochondrial DynamicPhysiology +7

Mitochondrial NADP(H) generation is essential for proline biosynthesis

Jiajun Zhu, Simon Schwörer, Mirela Berisa, +6

Science

Prevalence of mutations in a panel of breast cancer susceptibility genes in BRCA1/2-negative patients with early-onset breast cancer

Kara N. Maxwell, Bradley Wubbenhorst, Kurt D’Andrea, +11

Genetics in Medicine

Brca1/2-negative PatientsOncologyBreast OncologySomatic VariantMedicine +6