Concepedia

Exosomal transfer leads to chemoresistance through oxidative phosphorylation-mediated stemness phenotype in colorectal cancer

Jinhai Deng, Teng Pan, Chunxin Lv, Lulu Cao, Lifeng Li, Xingang Zhou, Gang Li, Huanxin Li, José M. Vicencio, Yihan Xu,

Theranostics · 2023 · 38 citations · 39 references

DOIFull text

Open access

Concepts

Abstract

Our data suggests that exosomal circ_0001610-induced OXPHOS plays an important role in chemoresistance and supports a therapeutical potential of circ_0001610 inhibitors in the treatment of oxaliplatin-resistant colorectal cancer by manipulating cell stemness.

References

39

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Hadi Valadi, Karin M. Ekström, Apostolos Bossios et al. · Nature Cell Biology · 2007 · 12.8K citations

, , +12

Circular RNAs are a large class of animal RNAs with regulatory potency

Sebastian Memczak, Marvin Jens, Antigoni Elefsinioti et al. · Nature · 2013 · 8.5K citations

, , +13

Natural RNA circles function as efficient microRNA sponges

Thomas B. Hansen, Trine I. Jensen, Bettina Hjelm Clausen et al. · Nature · 2013 · 8.5K citations

, , +10

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Frank Weinberg, Robert B. Hamanaka, William W. Wheaton et al. · Proceedings of the National Academy of Sciences · 2010 · 1.7K citations

, , +17

Hallmarks of Cancer: The Next Generation

Michael F. Roizen · Yearbook of Anesthesiology and Pain Management · 2012 · 1.5K citations

, , +12