Concepedia

Incorporating a β-hairpin sequence motif to increase intracellular stability of a peptide-based PROTAC

Hannah C. Hymel, Jeffery C. Anderson, Dong Liu, Ted J. Gauthier, Adam T. Melvin

Biochemical Engineering Journal · 2023 · 10 citations · 23 references

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Concepts

References

23

Chemical Genetic Control of Protein Levels:  Selective in Vivo Targeted Degradation

John S. Schneekloth, Fabiana N. Fonseca, Michael A. Koldobskiy et al. · Journal of the American Chemical Society · 2004 · 467 citations

, , +17

The Outstanding Biological Stability ofβ- andγ-Peptides toward Proteolytic Enzymes: An In Vitro Investigation with Fifteen Peptidases

Jens Frackenpohl, Per I. Arvidsson, Jürg V. Schreiber et al. · ChemBioChem · 2001 · 406 citations

, , +17

Discovery and Mechanism of Highly Efficient Cyclic Cell-Penetrating Peptides

Ziqing Qian, Agnieszka Martyna, Ryan Hard et al. · Biochemistry · 2016 · 299 citations · Full text

, , +17

Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway

Mengchen Lu, Tian Liu, Qiong Jiao et al. · European Journal of Medicinal Chemistry · 2018 · 292 citations · Full text

, , +13

Specific Knockdown of Endogenous Tau Protein by Peptide-Directed Ubiquitin-Proteasome Degradation

Tingting Chu, Na Gao, Qianqian Li et al. · Cell chemical biology · 2016 · 241 citations · Full text

, , +15