Concepedia

Peptide Stability Engineering

Peptide Stability Engineering is a methodological framework within peptide drug discovery that systematically modifies physicochemical properties and structural features of peptides to enhance their metabolic and conformational stability without compromising biological activity.

130

Publications

7.4K

Citations

698

Authors

250

Institutions

Publications per year

2017–2026

46

Parents

Publications

130

An All-Hydrocarbon Cross-Linking System for Enhancing the Helicity and Metabolic Stability of Peptides

Christian E. Schafmeister, Julia Po, Gregory L. Verdine · Journal of the American Chemical Society · 2000 · 1K citations

, , +13

The emergence of peptides in the pharmaceutical business: From exploration to exploitation

Thomas Uhlig, Themis Kyprianou, Filippo Martinelli et al. · EuPA Open Proteomics · 2014 · 447 citations · Full text

, , +16

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

Karen S. Harris, Thomas Durek, Quentin Kaas et al. · Nature Communications · 2015 · 261 citations · Full text

, , +16

Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the α-conotoxin MII

Richard J. Clark, Harald Fischer, L. Dempster et al. · Proceedings of the National Academy of Sciences · 2005 · 231 citations · Full text

, , +16

Engineering Stabilized Vascular Endothelial Growth Factor-A Antagonists: Synthesis, Structural Characterization, and Bioactivity of Grafted Analogues of Cyclotides

Sunithi Gunasekera, Fiona Foley, Richard J. Clark et al. · Journal of Medicinal Chemistry · 2008 · 180 citations

, , +17

1–5 of 130

Authors

698

  1. DJ
    David J. Craik

    The University of Queensland, Australia

    7 publications · 885 citations

    7

    h-index

  2. NL
    Norelle L. Daly

    The University of Queensland, Australia

    4 publications · 784 citations

    4

    h-index

  3. AS
    Anshan Shan

    Northeast Agricultural University, China

    4 publications · 238 citations

    4

    h-index

  4. PT
    Peng Tan

    Northeast Agricultural University, China

    3 publications · 224 citations

    3

    h-index

  5. SU
    Susumu Uchiyama

    The University of Osaka, Japan

    3 publications · 203 citations

    3

    h-index

1–5 of 698

Institutions

250

  1. The University of Queensland

    Brisbane, Australia

    10 h-index

    53 publications

    6.5K citations

  2. Northeast Agricultural University

    Harbin, China

    4 h-index

    25 publications

    1.5K citations

  3. The University of Osaka

    Osaka, Japan

    3 h-index

    11 publications

    896 citations

  4. The University of Tokyo

    Tokyo, Japan

    3 h-index

    11 publications

    361 citations

  5. Rutgers, The State University of New Jersey

    New Brunswick, United States

    3 h-index

    6 publications

    141 citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    7 publications

    180 citations

  7. North Carolina State University

    Raleigh, United States

    2 h-index

    2 publications

    33 citations

  8. Australian Research Council

    Canberra, Australia

    2 h-index

    9 publications

    312 citations

1–8 of 250

Venues

  1. Journal of Medicinal Chemistry

    12 publications · 648 citations

    12

    h-index

  2. Angewandte Chemie International Edition

    6 publications · 377 citations

    6

    h-index

  3. Journal of the American Chemical Society

    JACS · 6 publications · 1.5K citations

    6

    h-index

  4. Organic & Biomolecular Chemistry

    6 publications · 165 citations

    6

    h-index

  5. Organic Letters

    OL · 4 publications · 81 citations

    4

    h-index

1–5