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Publication | Open Access

Glioma Metabolic Feedback In Situ: A First-In-Human Pharmacodynamic Trial of Difluoromethylornithine + AMXT-1501 Through High–Molecular Weight Microdialysis

DOIFull Paper Access

12

Citations

30

References

2023

Year

Cécile Riviere-Cazaux, Bryan J. Neth, Matthew D. Hoplin, Bambi Wessel, Jason Miska, Sani H. Kizilbash, Terry C. Burns
Neurosurgery

Abstract

Limited mechanistic feedback from individual patients' gliomas hampers clinical translation of novel therapies. This pilot Phase 0 study will provide in situ feedback during DFMO + AMXT-1501 treatment to determine how high-grade gliomas respond to polyamine depletion.

References

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