Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Mamta Tahiliani, Kian Peng Koh, Yinghua Shen et al. · Science · 2009 · 5.7K citations · Full text

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Shinsuke Ito, Ana C. D’Alessio, Olena Taranova et al. · Nature · 2010 · 2.5K citations

Signal Transduction, Cell Regulation, Molecular Biology +9

ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD

Lars Rydén, Peter J. Grant, Stefan D. Anker et al. · European Heart Journal · 2013 · 1.9K citations · Full text

Metabolic Syndrome, Diabetes Management, Diabetes Epidemiology +11

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

Sanjeev Shukla, Erşen Kavak, Melissa K. Gregory et al. · Nature · 2011 · 971 citations · Full text

Chromatin, Transcriptional Regulation, Natural Sciences +13

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

Bryce W. Carey, Lydia W.S. Finley, Justin R. Cross et al. · Nature · 2014 · 963 citations

Induced Pluripotent Stem Cell, Developmental Biology, Medicine +6