Improved protein production in yeast using cell engineering with genes related to a key factor in the unfolded protein response

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love, Wolfgang Huber, Simon Anders · Genome biology · 2014 · 100.5K citations · Full text

Life Sciences, Bioinformatics, Biostatistics +15

BEDTools: a flexible suite of utilities for comparing genomic features

Aaron R. Quinlan, Ira M. Hall · Bioinformatics · 2010 · 30.4K citations · Full text

Life Sciences, Bioinformatics, Genetics +14

HISAT: a fast spliced aligner with low memory requirements

Daehwan Kim, Ben Langmead, Steven L. Salzberg · Nature Methods · 2015 · 26.1K citations · Full text

Engineering, Computer Engineering, Computer Science +3

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

Mihaela Pertea, Geo Pertea, Corina Antonescu et al. · Nature Biotechnology · 2015 · 15.5K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +10

Enzymatic assembly of DNA molecules up to several hundred kilobases

Daniel G. Gibson, Lei Young, Ray-Yuan Chuang et al. · Nature Methods · 2009 · 10.9K citations

Life Sciences, Biochemistry, Molecular Biology +16