Concepedia

Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5

Anthony Tumber, E. Salah, Lennart Brewitz, Thomas P. Corner, Christopher J. Schofield

RSC Chemical Biology · 2023 · 15 citations · 80 references

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Concepts

Abstract

roxadustat) do not inhibit JMJD5. The SPE-MS assays will help enable the development of efficient and selective JMJD5 inhibitors for investigating the biochemical functions of JMJD5 in cellular studies.

References

80

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 7K citations · Full text

, , +16

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Laurens Kruidenier, Chun‐wa Chung, Zhongjun Cheng et al. · Nature · 2012 · 958 citations · Full text

, , +14

JMJD6 Is a Histone Arginine Demethylase

Bingsheng Chang, Yue Chen, Yingming Zhao et al. · Science · 2007 · 731 citations

, , +14

Carnitine biosynthesis in mammals

Frédéric M. Vaz, Ronald J. A. Wanders · Biochemical Journal · 2002 · 534 citations

, , +14

Catalytic Properties of the Asparaginyl Hydroxylase (FIH) in the Oxygen Sensing Pathway Are Distinct from Those of Its Prolyl 4-Hydroxylases

Peppi Koivunen, Maija Hirsilä, Volkmar Günzler et al. · Journal of Biological Chemistry · 2004 · 441 citations · Full text

, , +15