Peppi Koivunen

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

Gommaar D’Hulst, Inés Soro-Arnáiz, Evi Masschelein et al. · Nature Communications · 2020 · 2.3K citations · Full text

Life Sciences, Biochemistry, Physiology +17

Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor

Maija Hirsilä, Peppi Koivunen, Volkmar Günzler et al. · Journal of Biological Chemistry · 2003 · 789 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

Peppi Koivunen, Sung-Woo Lee, Christopher G. Duncan et al. · Nature · 2012 · 722 citations · Full text

Medicine, Biochemistry, Metabolism +2

( <i>R</i> )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

Julie-Aurore Losman, Ryan Looper, Peppi Koivunen et al. · Science · 2013 · 710 citations · Full text

Medicine, Biochemistry, Oncology +12

Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates

Peppi Koivunen, Maija Hirsilä, Anne M. Remes et al. · Journal of Biological Chemistry · 2006 · 520 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16