Julie-Aurore Losman

( <i>R</i> )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

Julie-Aurore Losman, Ryan Looper, Peppi Koivunen et al. · Science · 2013 · 710 citations · Full text

Medicine, Biochemistry, Oncology +12

Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation

Shannon Elf, Nouran S. Abdelfattah, Edwin Chen et al. · Cancer Discovery · 2016 · 282 citations · Full text

Medicine, Hematology, Oncology +15

The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies

Sven Christian, Claudia Merz, Laura Evans et al. · Leukemia · 2019 · 246 citations · Full text

Medicine, Hematology, Pharmacology +17

De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

Diana D. Shi, Milan R. Savani, Michael M. Levitt et al. · Cancer Cell · 2022 · 129 citations · Full text

Medicine, Cancer Biology, Oncology +15

Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma

James M. Cleary, Betty Rouaisnel, Antoine Daina et al. · npj Precision Oncology · 2022 · 78 citations · Full text

Medicine, Oncology, Pharmacology +17