Design, synthesis and anti-AD effects of dual inhibitor targeting glutaminyl cyclase/GSK-3β

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

Justin Nussbaum, Stephan Schilling, Holger Cynis et al. · Nature · 2012 · 429 citations · Full text

Life Sciences, Biochemistry, Neuroscience +16

ADP-Glo: A Bioluminescent and Homogeneous ADP Monitoring Assay for Kinases

Hicham Zegzouti, Marina V. Zdanovskaia, Kevin Hsiao et al. · Assay and Drug Development Technologies · 2009 · 279 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides

Dagmar Schlenzig, Susanne Manhart, Yeliz Cinar et al. · Biochemistry · 2009 · 224 citations

Life Sciences, Biochemistry, Molecular Biology +17

2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole Derivatives as Novel Inhibitors of Glycogen Synthase Kinase-3β with Good Brain Permeability

Morihisa Saitoh, Jun Kunitomo, Eiji Kimura et al. · Journal of Medicinal Chemistry · 2009 · 125 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Glutaminyl Cyclase in Human Cortex: Correlation with (pGlu)-Amyloid-β Load and Cognitive Decline in Alzheimer's Disease

Markus Morawski, Stephan Schilling, Moritz Kreuzberger et al. · Journal of Alzheimer s Disease · 2014 · 108 citations · Full text

Life Sciences, Neurology, Neuroscience +17