Holger Cynis

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

Justin Nussbaum, Stephan Schilling, Holger Cynis et al. · Nature · 2012 · 420 citations · Full text

Neurodegenerative Diseases, Biochemistry, Prion-like Behaviour +5

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

Stephan Schilling, Ulrike Zeitschel, Torsten Hoffmann et al. · Nature Medicine · 2008 · 345 citations

Glutaminyl Cyclase Inhibition, Neurodegenerative Diseases, Molecular Neuroscience +10

Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

Oliver Wirths, Henning Breyhan, Holger Cynis et al. · Acta Neuropathologica · 2009 · 172 citations · Full text

Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-β

Holger Cynis, Eike Scheel, Takaomi C. Saido et al. · Biochemistry · 2008 · 116 citations

Pyroglutamate-3 Amyloid-β Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease–Like Transgenic Mouse Models

Jeffrey L. Frost, Kevin X. Le, Holger Cynis et al. · American Journal Of Pathology · 2013 · 113 citations · Full text