Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

Justin Nussbaum, Stephan Schilling, Holger Cynis, +15

Nature

Neurodegenerative DiseasesBiochemistryPrion-like BehaviourDegenerative PathologyPrion Disease +3

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

Stephan Schilling, Ulrike Zeitschel, Torsten Hoffmann, +15

Nature Medicine

Glutaminyl Cyclase InhibitionNeurodegenerative DiseasesMolecular NeuroscienceAlzheimer's DiseaseMedicine +8

Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

Oliver Wirths, Henning Breyhan, Holger Cynis, +3

Acta Neuropathologica

Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-β

Holger Cynis, Eike Scheel, Takaomi C. Saido, +2

Biochemistry

Pyroglutamate-3 Amyloid-β Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease–Like Transgenic Mouse Models

Jeffrey L. Frost, Kevin X. Le, Holger Cynis, +13

American Journal Of Pathology

Glutaminyl Cyclase in Human Cortex: Correlation with (pGlu)-Amyloid-β Load and Cognitive Decline in Alzheimer's Disease

Markus Morawski, Stephan Schilling, Moritz Kreuzberger, +9

Journal of Alzheimer s Disease

AgingNeurochemical BiomarkersTemporal CortexSocial SciencesNeuroinflammation +22

Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated Aβ Is Induced by Pyroglutamate–Aβ Formation

Anca Alexandru, Wolfgang Jagla, Sigrid Graubner, +15

Journal of Neuroscience

Synaptic TransmissionCell DeathPosttranslational Amyloid-βSynaptic SignalingSocial Sciences +20

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions

Holger Cynis, Torsten Hoffmann, Daniel Friedrich, +24

EMBO Molecular Medicine

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells

Holger Cynis, Stephan Schilling, Mandy Bodnár, +4

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

BiochemistryMammalian CellsNatural SciencesMedicinePhysiology +6

N‐Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long‐term potentiation

Dagmar Schlenzig, Raik Rönicke, Holger Cynis, +7

Journal of Neurochemistry

Danish DementiaSynaptic TransmissionNeurochemical BiomarkersSynaptic SignalingSocial Sciences +23