Concepedia

ALKBH5 activates FAK signaling through m6A demethylation in <i>ITGB1</i> mRNA and enhances tumor-associated lymphangiogenesis and lymph node metastasis in ovarian cancer

Rui Sun, Lin Yuan, Yi Jiang, Yicong Wan, Xiaolling Ma, Jing Yang, Guodong Sun, Shulin Zhou, Hui Wang, Jiangnan Qiu,

Theranostics · 2023 · 86 citations · 36 references

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Abstract

The ALKBH5/m6A-ITGB1/FAK signalling axis is important in ovarian cancer lymphangiogenesis and LN metastasis. Antibodies that block ITGB1 and FAK kinase-inhibitors are promising anti-metastatic agents.

References

36

Cancer Statistics, 2021

Rebecca L. Siegel, Kimberly D. Miller, Hannah E. Fuchs et al. · CA A Cancer Journal for Clinicians · 2021 · 17.4K citations · Full text

, , +16

starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data

Jun-Hao Li, Shun Liu, Hui Zhou et al. · Nucleic Acids Research · 2013 · 6K citations · Full text

, , +16

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang, Hengyou Weng, Wenju Sun et al. · Nature Cell Biology · 2018 · 3.1K citations

, , +16

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m <sup>6</sup> A-demethylation of NANOG mRNA

Chuanzhao Zhang, Debangshu Samanta, Haiquan Lu et al. · Proceedings of the National Academy of Sciences · 2016 · 1K citations · Full text

, , +17

VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis

Satoshi Hirakawa, Shohta Kodama, Rainer Kunstfeld et al. · The Journal of Experimental Medicine · 2005 · 719 citations · Full text

, , +17