Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m ⁶ A-demethylation of NANOG mRNA

Chuanzhao Zhang, Debangshu Samanta, Haiquan Lu, +5

Proceedings of the National Academy of Sciences

HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells

Huimin Zhang, Haiquan Lu, Lisha Xiang, +6

Proceedings of the National Academy of Sciences

Cd47 GeneBreast OncologyCd47 ExpressionCell RegulationMedicine +10

Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells

Chuanzhao Zhang, Wanqing Iris Zhi, Haiquan Lu, +4

Oncotarget

Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype

Haiquan Lu, Debangshu Samanta, Lisha Xiang, +5

Proceedings of the National Academy of Sciences

Copper ChelationBreast OncologyChemoprevention StrategyCancer BiologyTumor Biology +14

Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment

Haiquan Lu, Ivan Chen, Larissa A. Shimoda, +5

Cell Reports

Tumor BiologyBreast OncologyMedicineBreast CancerCancer Biology +4

Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness

Haiquan Lu, Yangyiran Xie, Thi My Linh Tran, +6

Journal of Clinical Investigation

Breast OncologyCancer BiologyTumor BiologyTranscriptional RegulationCancer Cell Biology +15

Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment

Jie Lan, Haiquan Lu, Debangshu Samanta, +3

Proceedings of the National Academy of Sciences

Breast OncologyChemoprevention StrategyImmunologyCell DeathAdenosine Receptor 2B +18

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

Lisha Xiang, Daniele M. Gilkes, Hongxia Hu, +7

Oncotarget

HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia

Yongkang Yang, Haiquan Lu, Chelsey Chen, +3

Nature Communications

Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis

Ru Wang, Inês Godet, Yongkang Yang, +10

Proceedings of the National Academy of Sciences