Pharmaceutical Biology · 2022 · 30 citations · 30 references
PharmacyPharmaceuticsPharmacokineticsBioavailabilityDrug DeliveryNanoparticle Drug DeliveryDrug EncapsulationNanocarriers For TherapeuticsNanomaterials For Drug DeliveryNanomedicineNanoparticle Delivery SystemsNanoparticle FormulationsLipid NanomaterialsLipid Nanoparticle Delivery SystemsLipid Nanoparticle StabilityLipid Nanoparticle SynthesisLipid NanoparticlesLipid-based Nanoparticle FormulationSolid Lipid Nanoparticle EncapsulationSustained Release Kinetics
CONTEXT: Curcumin (Cur) has a short duration of action which limits its therapeutic efficacy. Carbonic acid 17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 4-[7-(4-hydroxy-3-methoxy-phenyl)-3,5-dioxo-hepta-1,6-dienyl]-2-methoxy-phenyl ester (CUD), as a small molecule derivative of Cur with superior stability, has been developed in our laboratory. OBJECTIVE: CUD-loaded solid lipid nanoparticles (CUD-SLN) were prepared to prolong the duration of the drug action of Cur. MATERIALS AND METHODS: release of CUD and CUD-SLN was investigated. CUD-SLN (5 mg/kg) was injected into Sprague Dawley (SD) rats to investigate its pharmacokinetic behaviour. RESULTS: ) of 37.0-fold. CONCLUSIONS: CUD-SLN is a promising preparation for the development of a small molecule derivative of Cur.
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Enhancing the oral bioavailability of curcumin using solid lipid nanoparticles
Choongjin Ban, Myeongsu Jo, Young Hyun Park et al. · Food Chemistry · 2019 · 225 citations