Oxyberberrubine, a novel liver microsomes-mediated secondary metabolite of berberine, alleviates hyperuricemic nephropathy in mice

Decreased extra-renal urate excretion is a common cause of hyperuricemia

Kimiyoshi Ichida, Hirotaka Matsuo, Tappei Takada et al. · Nature Communications · 2012 · 691 citations · Full text

Medicine, Nephrology, Physiology +11

The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial

Michael A. Becker, H. Ralph Schumacher, Luis R. Espinoza et al. · Arthritis Research & Therapy · 2010 · 528 citations · Full text

Pharmacy, Nephrology, Pharmacotherapy +13

<i>In vitro</i> models for liver toxicity testing.

Valerie Y. Soldatow, Edward L. LeCluyse, Linda G. Griffith et al. · PubMed · 2013 · 460 citations

Life Sciences, Cell Biology, Toxicology +16

Hyperuricemia in Young Adults and Risk of Insulin Resistance, Prediabetes, and Diabetes: A 15-Year Follow-up Study

Eswar Krishnan, Bhavik J. Pandya, Leland W.K. Chung et al. · American Journal of Epidemiology · 2012 · 269 citations · Full text

Medicine, Chronic Disease Prevention, Adolescent Health +15

Tissue Distribution of Berberine and Its Metabolites after Oral Administration in Rats

Xiang‐Shan Tan, Jingyi Ma, Ru Feng et al. · PLoS ONE · 2013 · 256 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +13