Concepedia

<i>Senegalia macrostachya</i> seed polysaccharides attenuate inflammation-induced intestinal epithelial barrier dysfunction in a Caco-2 and RAW264.7 macrophage co-culture model by inhibiting the NF-κB/MLCK pathway

Abel Wend‐Soo Zongo, Daniel Zogona, Mahmoud Youssef, Shuxin Ye, Fuchao Zhan, Jing Li, Bin Li

Food & Function · 2022 · 37 citations · 49 references

DOI

Concepts

Abstract

Senegalia macrostachya seed polysaccharides improved the Caco-2 cell monolayer integrity from the inflammatory insult. SMSP2 treatment lowered the inflammatory cytokine release, increased TJ proteins, and downregulated the NF-κB/MLCK pathway.

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