<i>Faecalibacterium prausnitzii</i> Attenuates CKD via Butyrate-Renal GPR43 Axis

Abstract

Using a mouse CKD model, we uncovered a novel beneficial role of <i>F prausnitzii</i> in the restoration of renal function in CKD, which is, at least in part, attributed to the butyrate-mediated GPR-43 signaling in the kidney. Our study provides the necessary foundation to harness the therapeutic potential of <i>F prausnitzii</i> for ameliorating CKD.