Concepedia

Investigation into the anti-airway inflammatory role of the PI3Kγ inhibitor JN-PK1: An in vitro and in vivo study

Wendian Xiong, Lei Jia, Junjie Liang, Yanfei Cai, Yun Chen, Yunjuan Nie, Jian Jin, Jingyu Zhu

International Immunopharmacology · 2022 · 11 citations · 35 references

DOI

Concepts

References

35

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

Emilio Hirsch, Vladimir L. Katanaev, Cecília Garlanda et al. · Science · 2000 · 1.2K citations

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Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

Montserrat Camps, Thomas Rückle, Hong Ji et al. · Nature Medicine · 2005 · 751 citations

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Modulation of Airway Inflammation by Passive Transfer of Allergen-Specific Th1 and Th2 Cells in a Mouse Model of Asthma

David A. Randolph, Cynthia J. L. Carruthers, Susanne J. Szabo et al. · The Journal of Immunology · 1999 · 264 citations · Full text

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PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models

David G. Winkler, Jonathan P. DiNitto, Janid A. Ali et al. · Chemistry & Biology · 2013 · 258 citations

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Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling

Jianping Zhao, Clare M. Lloyd, Alistair Noble · Mucosal Immunology · 2012 · 217 citations · Full text

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