Concepedia

Thomas Rückle

TR

36

Publications

4.4K

Citations

33

H-Index

1999

Active since

Affiliations

Merck Serono (Switzerland)(Current)

Medicines for Malaria Venture

University of Turin

University of Basel

Q-Pharm

Thomas Rückle is an author at Merck Serono (Switzerland) specializing in medicine, immunology, and cell signaling.

Top concepts

MedicineImmunologyPharmacologyCell SignalingCell BiologyBiochemistryInflammationDrug DiscoveryAutoimmune DiseaseAutoimmunity

Publications per year

1999–2021

36

Publications

36

Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

Montserrat Camps, Thomas Rückle, Hong Ji et al. · Nature Medicine · 2005 · 742 citations

Immunology, Immune Regulation, Cell Death +16

PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

Domingo F. Barber, Almira Bartolomé, Carmen Hernández et al. · Nature Medicine · 2005 · 308 citations

Glomerular Disease, Immunology, Pathology +19

The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

Alex Berndt, Simon Miller, Olusegun Williams et al. · Nature Chemical Biology · 2010 · 285 citations · Full text

Molecular Pharmacology, Biochemistry, Medicine +13

Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

Elisa Ciraolo, Manuela Iezzi, Romina Marone et al. · Science Signaling · 2008 · 262 citations · Full text

Breast Oncology, Key Role, Metabolic Remodeling +24

Key role of the p110δ isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110δ function in B cells

Antonio Bilancio, Klaus Okkenhaug, Montserrat Camps et al. · Blood · 2005 · 210 citations

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