Concepedia

Identification of a cytokine profile in serum and cerebrospinal fluid of pediatric and adult spinal muscular atrophy patients and its modulation upon nusinersen treatment

Silvia Bonanno, Paola Cavalcante, Erika Salvi, Eleonora Giagnorio, Claudia Malacarne, Marco Cattaneo, Francesca Andreetta, Anna Venerando, Viviana Pensato, Cinzia Gellera,

Frontiers in Cellular Neuroscience · 2022 · 26 citations · 25 references

DOIFull text

Open access

Abstract

Pediatric and adult SMA patients show an inflammatory signature in serum that is reduced upon <i>SMN2</i> modulating treatment, and the presence of inflammatory mediators in CSF. Our findings enhance SMA knowledge with potential clinical and therapeutic implications.

References

25

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Claire L. Langrish, Yi Chen, Wendy M. Blumenschein et al. · The Journal of Experimental Medicine · 2005 · 4K citations · Full text

Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy

Jerry R. Mendell, Samiah Al-Zaidy, Richard Shell et al. · New England Journal of Medicine · 2017 · 2.2K citations · Full text

Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy

Richard S. Finkel, Eugenio Mercuri, Basil T. Darras et al. · New England Journal of Medicine · 2017 · 2.2K citations · Full text

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

Eva V. Acosta Rodríguez, Giorgio Napolitani, Antonio Lanzavecchia et al. · Nature Immunology · 2007 · 1.8K citations

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Evidence that interleukin‐6 is produced in human skeletal muscle during prolonged running

Thomas Rohde, M. Zacho, S. Asp et al. · The Journal of Physiology · 1998 · 668 citations · Full text

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