Concepedia

Nusinersen Therapy

Nusinersen Therapy is a pharmacotherapeutic intervention classified as an antisense oligonucleotide-based treatment that selectively modulates SMN2 gene splicing to increase production of functional survival motor neuron protein in patients with spinal muscular atrophy.

246

Publications

16.5K

Citations

1.8K

Authors

561

Institutions

Publications per year

2017–2026

243

Parents

Publications

246

Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy

Richard S. Finkel, Eugenio Mercuri, Basil T. Darras et al. · New England Journal of Medicine · 2017 · 2.3K citations · Full text

, , +17

Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy

Eugenio Mercuri, Basil T. Darras, Claudia A. Chiriboga et al. · New England Journal of Medicine · 2018 · 1.4K citations · Full text

, , +17

Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study

Richard S. Finkel, Claudia A. Chiriboga, Jiri Vajsar et al. · The Lancet · 2016 · 1K citations

, , +9

Nusinersen initiated in infants during the presymptomatic stage of spinal muscular atrophy: Interim efficacy and safety results from the Phase 2 NURTURE study

Darryl C. De Vivo, Enrico Bertini, Kathryn J. Swoboda et al. · Neuromuscular Disorders · 2019 · 626 citations · Full text

, , +10

Results from a phase 1 study of nusinersen (ISIS-SMN <sub>Rx</sub> ) in children with spinal muscular atrophy

Claudia A. Chiriboga, Kathryn J. Swoboda, Basil T. Darras et al. · Neurology · 2016 · 602 citations · Full text

, , +14

1–5 of 246

Authors

1.8K

  1. TH
    Tim Hagenacker

    Essen University Hospital, Germany

    19 publications · 1.2K citations

    19

    h-index

  2. EM
    Eugenio Mercuri

    Università Cattolica del Sacro Cuore, Italy

    25 publications · 4.8K citations

    19

    h-index

  3. JK
    Janbernd Kirschner

    University Medical Center Freiburg, Germany

    23 publications · 5.8K citations

    19

    h-index

  4. DC
    Darryl C. De Vivo

    Columbia University, United States

    17 publications · 6.8K citations

    16

    h-index

  5. RS
    Richard S. Finkel

    Children's Hospital of Philadelphia, United States

    17 publications · 6.1K citations

    16

    h-index

1–5 of 1.8K

Institutions

561

  1. University of Freiburg

    Freiburg im Breisgau, Germany

    18 h-index

    81 publications

    10.4K citations

  2. Bambino Gesù Children's Hospital

    Rome, Italy

    17 h-index

    49 publications

    3.1K citations

  3. Biogen (United States)

    Cambridge, United States

    17 h-index

    102 publications

    26K citations

  4. Columbia University Irving Medical Center

    New York, United States

    16 h-index

    30 publications

    10.1K citations

  5. Centro Clinico Nemo

    Milan, Italy

    16 h-index

    109 publications

    5.7K citations

  6. University of Milan

    Milan, Italy

    15 h-index

    55 publications

    2.9K citations

  7. Università Cattolica del Sacro Cuore

    Milan, Italy

    15 h-index

    55 publications

    2.5K citations

  8. Medizinische Hochschule Hannover

    Hanover, Germany

    15 h-index

    94 publications

    4.3K citations

1–8 of 561

Venues

  1. Journal of Neuromuscular Diseases

    14 publications · 1K citations

    13

    h-index

  2. Muscle & Nerve

    13 publications · 642 citations

    13

    h-index

  3. Frontiers in Neurology

    10 publications · 259 citations

    11

    h-index

  4. Neurology

    10 publications · 1.2K citations

    11

    h-index

  5. Journal of Neurology

    10 publications · 608 citations

    11

    h-index

1–5