American Journal of Physiology-Endocrinology and Metabolism · 2022 · 21 citations · 70 references
Life SciencesNutritionNutritional SciencesHuman NutritionNutritional BiochemistryPediatric NutritionBile Acid MetabolismBile SecretionLipid MetabolismLiver DiseaseMetabolic Liver DiseaseNutrition In Liver DiseaseBile Acid Homeostasis In DiseaseBile Acid PhysiologyBile Acid Signaling In Liver PhysiologyDietary Fat CompositionDietary Fatty Acid CompositionIntestinal Bile Acid MetabolismLiver Injury ModelsSerum Bile Acid
Bile acid homeostasis and signaling is disrupted in NAFLD and may play a central role in the development of the disease. However, there are no studies addressing the impact of diet on bile acid metabolism in patients with NAFLD. In juvenile Iberian pigs, we show that fatty acid composition in high-fat high-fructose diets affects BA levels in liver, plasma, and colon but these changes were not associated with the severity of the disease.
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