Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha, +8

Proceedings of the National Academy of Sciences

GeneticsGenomicsGene RecognitionBioinformatics DatabaseGene Expression Profiling +21

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu, Li-Gen Wang, Yanyan Han, +1

OMICS A Journal of Integrative Biology

GeneticsGenomicsGene RecognitionBioinformatics DatabaseR Package +22

Histone H3K27ac separates active from poised enhancers and predicts developmental state

Menno P. Creyghton, Albert W. Cheng, G. Grant Welstead, +10

Proceedings of the National Academy of Sciences

Histone ModificationsEpigenetic ChangeGeneticsEpigeneticsDevelopmental Programs +18

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Warren A. Whyte, David A. Orlando, Denes Hnisz, +6

Cell

Transcriptional RegulationDevelopmental BiologyCell RegulationTranscription RegulationGene Regulation +7

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Nicole M. Gaudelli, Alexis C. Komor, Holly A. Rees, +4

Nature

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

Vasily Ogryzko, R. Louis Schiltz, Valya Russanova, +2

Cell

ChromatinTranscriptional RegulationChromatin StructureChromatin RemodelingNatural Sciences +8

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

Luke A. Gilbert, Max A. Horlbeck, Britt Adamson, +10

Cell

Transcriptional RegulationGeneticsGenetic EngineeringGene RepressionGene Editing +5

Mediator and cohesin connect gene expression and chromatin architecture

Michael H. Kagey, Jamie J. Newman, Steve Bilodeau, +10

Nature

ChromatinChromatin RemodelingGeneticsNuclear OrganizationGene Expression +3

Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells

Katsuhiko Hayashi, Hiroshi Ohta, Kazuki Kurimoto, +2

Cell

Embryo CultureGerm Cell BiologyInduced Pluripotent Stem CellDevelopmental BiologyPluripotent Stem Cells +9

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

Peter W. Lewis, Manuel M. Müller, Matthew S. Koletsky, +7

Science

Histone ModificationsEpigenetic ChangeMolecular BiologyHigh-grade GliomasHistone H3.3 +20