Concepedia

STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program

Luis Eduardo Alves Damasceno, Guilherme Cesar Martelossi Cebinelli, Mariane Font Fernandes, Daniele C. Nascimento, Gabriel Azevedo Públio, Marco Aurélio Ramirez Vinolo, Sérgio C. Oliveira, Tim Sparwasser, Thiago M. Cunha, Fernando Q. Cunha,

Cell Reports · 2022 · 23 citations · 53 references

DOIFull text

Open access

Concepts

Abstract

17-cell-mediated inflammation.

References

53

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

Linda Madisen, Theresa A. Zwingman, Susan M. Sunkin et al. · Nature Neuroscience · 2009 · 7.4K citations · Full text

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Estelle Bettelli, Yijun Carrier, Wenda Gao et al. · Nature · 2006 · 6.9K citations

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The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou et al. · Cell · 2006 · 5.1K citations · Full text

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Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Lijun Sun, Jiaxi Wu, Fenghe Du et al. · Science · 2012 · 4.8K citations

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Claire L. Langrish, Yi Chen, Wendy M. Blumenschein et al. · The Journal of Experimental Medicine · 2005 · 4K citations · Full text

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