Concepedia

Publication | Open Access

Rational design of chimeric antigen receptor T cells against glypican 3 decouples toxicity from therapeutic efficacy

DOIFull Paper Access

23

Citations

35

References

2022

Year

Maria Letizia Giardino Torchia, Ryan Gilbreth, Ashley A. Merlino, Erin Sult, Noel R. Monks, Jon Chesebrough, Ravinder Tammali, Nina Chu, Jessica Tong, John Meekin,
Cytotherapy

Abstract

By combining the reduced-affinity CAR with this exogenous control mechanism, we provide evidence that we can modulate and control CAR-mediated toxicity.

References

YearCitations

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