Angewandte Chemie · 2008 · 41 citations · 29 references
Life SciencesBiochemistryMolecular BiologyCatalysisEnzyme MechanismEnzymologyCatalytic MechanismsEnzyme CatalysisEnzyme FunctionEnzyme StructureEnzyme-substrate RecognitionStructural EnzymologyAldol CondensationAldolase MechanismEnzyme FoldingHelical Structure AnalysisImine CatalysisPeptide FoldingProtein Folding CatalysisProtein Folding Of Enzymes
Ordentlich gefaltet: Ein dekameres β-Peptid weist enzymähnliche katalytische Eigenschaften auf. Das Foldamer enthält eine terminale Heptanoyleinheit und hat ein thermostabiles Gerüst, das Seitenketten mit Ammoniumgruppen anordnet. Durch einen Iminmechanismus beschleunigt es eine Retroaldolreaktion (siehe Schema) um mehr als drei Größenordnungen. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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