Combinations of ATR, Chk1 and Wee1 Inhibitors with Olaparib Are Active in Olaparib Resistant Brca1 Proficient and Deficient Murine Ovarian Cells - Concepedia

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Combinations of ATR, Chk1 and Wee1 Inhibitors with Olaparib Are Active in Olaparib Resistant Brca1 Proficient and Deficient Murine Ovarian Cells

DOI Full Paper Access

22

Citations

45

References

2022

Year

Michela Chiappa, Federica Guffanti, Martina Anselmi, Monica Lupi, Nicolò Panini, Lisa Wiesmüller, Giovanna Damia

Abstract

Olaparib-resistant cell lines were generated and displayed multiple mechanisms of resistance, which will be instrumental in selecting new possible therapeutic options for PARPi-resistant ovarian tumors.

References

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