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Discovery of ASP5878: Synthesis and structure–activity relationships of pyrimidine derivatives as pan-FGFRs inhibitors with improved metabolic stability and suppressed hERG channel inhibitory activity

Medicinal ChemistryPharmaceutical ScienceBiochemistryNatural SciencesMedicineRational Drug DesignStructure–activity RelationshipsDrug DevelopmentChemical BiologyPharmacologyPan-fgfrs InhibitorsDrug DiscoveryPyrimidine Derivatives