Kazuhiko Iikubo

The first direct synthesis of α-mangostin, a potent inhibitor of the acidic sphingomyelinase

Kazuhiko Iikubo, Yuichi Ishikawa, Noritaka Ando et al. · Tetrahedron Letters · 2002 · 73 citations

Life Sciences, Biochemistry, Pharmacology +12

Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2

Ikumi Kuriwaki, Minoru Kameda, Hiroyuki Hisamichi et al. · Bioorganic & Medicinal Chemistry · 2020 · 37 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Biological activities of α-mangostin derivatives against acidic sphingomyelinase

Motoko Hamada, Kazuhiko Iikubo, Yuichi Ishikawa et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 30 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +11

Synthesis and structure–activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists

Kenji Negoro, Yasuhiro Yonetoku, Ayako Moritomo et al. · Bioorganic & Medicinal Chemistry · 2012 · 22 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Discovery of <i>N</i>-{2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-<i>N</i>′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (ASP3026), a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor

Kazuhiko Iikubo, Yutaka Kondoh, Itsuro Shimada et al. · Chemical and Pharmaceutical Bulletin · 2018 · 17 citations · Full text

Medicine, Oncology, Pharmacology +15