Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice

Atsuo Tahara, Eiji Kurosaki, Masanori Yokono, +11

European Journal of Pharmacology

ObesityMetabolic SyndromeInflammationDiabetes ManagementMedicine +8

Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus

Masakazu Imamura, Keita Nakanishi, Takayuki Suzuki, +14

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryBenzothiophene StructureMedicineDiabetes +8

Effects of sodium-glucose cotransporter 2 selective inhibitor ipragliflozin on hyperglycaemia, oxidative stress, inflammation and liver injury in streptozotocin-induced type 1 diabetic rats

Atsuo Tahara, Eiji Kurosaki, Masanori Yokono, +11

Journal of Pharmacy and Pharmacology

Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo

Atsuo Tahara, Eiji Kurosaki, Masanori Yokono, +11

Naunyn-Schmiedeberg s Archives of Pharmacology

Anti-inflammatoryAllergyMedicinePharmacological AgentPharmacotherapy +5

Protein kinase inhibition by fasudil hydrochloride promotes neurological recovery after spinal cord injury in rats

Masahito Hara, Masakazu Takayasu, Kazuhiko Watanabe, +4

Journal of Neurosurgery Spine

Nitric Oxide Metabolites in the Cisternal Cerebral Spinal Fluid of Patients with Subarachnoid Hemorrhage

Yoshio Suzuki, Koji Osuka, Atsushi Noda, +4

Neurosurgery

Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: Discovery of YM543

Kazuhiro Ikegai, Masakazu Imamura, Takayuki Suzuki, +12

Bioorganic & Medicinal Chemistry

BiochemistryMedicineDiabetesType 2Azulene Rings +4

NER Rat Strain: A New Type of Genetic Model in Epilepsy Research

Atsushi Noda, Ryoichi Hashizume, Toshiro Maihara, +7

Epilepsia

Antidiabetic Effects of SGLT2-Selective Inhibitor Ipragliflozin in Streptozotocin^|^ndash;Nicotinamide-Induced Mildly Diabetic Mice

Atsuo Tahara, Eiji Kurosaki, Masanori Yokono, +11

Journal of Pharmacological Sciences

Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2

Ikumi Kuriwaki, Minoru Kameda, Hiroyuki Hisamichi, +13

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceMedicineDrug DiscoveryNatural Sciences +12