A Model Compound of the Novel Cofactor Tryptophan Tryptophylquinone of Bacterial Methylamine Dehydrogenases. Synthesis and Physicochemical Properties

Shinobu Itoh, Masaki Ogino, Shigenobu Haranou, +6

Journal of the American Chemical Society

Bacterial Methylamine DehydrogenasesBiosynthesisAldehyde DehydrogenaseBiochemistryNatural Sciences +9

A Highly Potent Non-Nucleoside Adenosine Deaminase Inhibitor:  Efficient Drug Discovery by Intentional Lead Hybridization

Tadashi Terasaka, Takayoshi Kinoshita, Masako Kuno, +1

Journal of the American Chemical Society

Drug TargetBioorganic ChemistryLead IdentificationEfficient Drug DiscoveryPharmacotherapy +15

Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938

Masako Kuno, Nobuo Seki, Susumu Tsujimoto, +7

European Journal of Pharmacology

InflammationInhibitory ActivityAnti-inflammatoryMedicinePharmacotherapy +3

Structural Basis of Compound Recognition by Adenosine Deaminase

Takayoshi Kinoshita, Isao Nakanishi, Tadashi Terasaka, +9

Biochemistry

BiochemistryNatural SciencesMolecular BiologyAdenosine DeaminaseOverall Conformation +12

ASP5878, a Novel Inhibitor of FGFR1, 2, 3, and 4, Inhibits the Growth of FGF19-Expressing Hepatocellular Carcinoma

T. Futami, Hidetsugu Okada, Rumi Kihara, +8

Molecular Cancer Therapeutics

Structure-Based Design, Synthesis, and Structure−Activity Relationship Studies of Novel Non-nucleoside Adenosine Deaminase Inhibitors

Tadashi Terasaka, Takayoshi Kinoshita, Masako Kuno, +3

Journal of Medicinal Chemistry

Molecular DockingCrystal StructureMedicinal ChemistryCombinatorial ChemistryBenzimidazole Ring +12

<scp>ASP</scp>5878, a selective <scp>FGFR</scp> inhibitor, to treat <scp>FGFR</scp>3‐dependent urothelial cancer with or without chemoresistance

Aya Kikuchi, Tomoyuki Suzuki, Taisuke Nakazawa, +8

Cancer Science

Structure-Based Design and Synthesis of Non-Nucleoside, Potent, and Orally Bioavailable Adenosine Deaminase Inhibitors

Tadashi Terasaka, Hiroyuki Okumura, Kiyoshi Tsuji, +10

Journal of Medicinal Chemistry

Combinatorial ChemistryCrystal StructureMedicinal ChemistryImproved Oral BioavailabilityPharmaceutical Science +13

Rational Design of Non-Nucleoside, Potent, and Orally Bioavailable Adenosine Deaminase Inhibitors: Predicting Enzyme Conformational Change and Metabolism

Tadashi Terasaka, Kiyoshi Tsuji, Takeshi Kato, +7

Journal of Medicinal Chemistry

Bioorganic ChemistryAldo-keto ReductaseEnzyme Conformational ChangePharmacotherapyChemical Biology +16

Structure-Based de novo design of non-nucleoside adenosine deaminase inhibitors

Tadashi Terasaka, Isao Nakanishi, Katsuya Nakamura, +7

Bioorganic & Medicinal Chemistry Letters

Rational Drug DesignOligonucleotideMolecular BiologyMolecular ModelingDrug Discovery