Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 <i>H</i> -pyrazolo[3,4- <i>c</i> ]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships

Masato Yoshikawa, Morihisa Saitoh, Taisuke Katoh, +14

Journal of Medicinal Chemistry

A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model

Misato Ito, Shunji Yamazaki, Kaoru Yamagami, +9

Journal of Pharmacological Sciences

ImmunologyPharmacotherapyInflammationRheumatoid DisorderNovel Jak Inhibitor +15

<i>In Vitro</i>and<i>in Vivo</i>Activities of T-705 and Oseltamivir against Influenza Virus

Kazumi Takahashi, Yousuke Furuta, Yoshiko Fukuda, +7

Antiviral chemistry & chemotherapy

A Highly Potent Non-Nucleoside Adenosine Deaminase Inhibitor:  Efficient Drug Discovery by Intentional Lead Hybridization

Tadashi Terasaka, Takayoshi Kinoshita, Masako Kuno, +1

Journal of the American Chemical Society

Drug TargetBioorganic ChemistryLead IdentificationEfficient Drug DiscoveryPharmacotherapy +15

Strain difference in the induction of T-cell activation-associated, interferon gamma-dependent hepatic injury in mice

Hidekazu Mizuhara, Masako Kuno, Nobuo Seki, +8

Hepatology

Nitric OxideT-regulatory CellImmunologyImmune RegulationPathology +22

CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens

Tsuyoshi Ishii, Takuro Okai, Misa Iwatani-Yoshihara, +8

Scientific Reports

Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938

Masako Kuno, Nobuo Seki, Susumu Tsujimoto, +7

European Journal of Pharmacology

InflammationInhibitory ActivityAnti-inflammatoryMedicinePharmacotherapy +3

Structural Basis of Compound Recognition by Adenosine Deaminase

Takayoshi Kinoshita, Isao Nakanishi, Tadashi Terasaka, +9

Biochemistry

BiochemistryNatural SciencesMolecular BiologyAdenosine DeaminaseOverall Conformation +12

Structure-Based Design, Synthesis, and Structure−Activity Relationship Studies of Novel Non-nucleoside Adenosine Deaminase Inhibitors

Tadashi Terasaka, Takayoshi Kinoshita, Masako Kuno, +3

Journal of Medicinal Chemistry

Molecular DockingCrystal StructureMedicinal ChemistryCombinatorial ChemistryBenzimidazole Ring +12

Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4<i>H</i>-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors

Takatoshi Yogo, Hiroyuki Nagamiya, Masaki Seto, +18

Journal of Medicinal Chemistry

Drug TargetTyk2 Inhibitory ActivityHeterocycle ChemistryChemical BiologyPharmaceutical Chemistry +14