Concepedia

Emodin ameliorates antioxidant capacity and exerts neuroprotective effect via PKM2-mediated Nrf2 transactivation

Zhenjiang Ding, Hong hong Da, Alsiddig Osama, Junmin Xi, Yanan Hou, Jianguo Fang

Food and Chemical Toxicology · 2021 · 33 citations · 51 references

DOI

Concepts

References

51

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Dimitrios Anastasiou, George Poulogiannis, John M. Asara et al. · Science · 2011 · 1.2K citations · Full text

, , +17

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

Weiwei Yang, Yan Xia, Haitao Ji et al. · Nature · 2011 · 1K citations · Full text

, , +7

Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription

H.-C. Huang, Truyen Nguyen, Cecil B. Pickett · Journal of Biological Chemistry · 2002 · 1K citations · Full text

, , +16

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

Weiwei Yang, Yanhua Zheng, Yan Xia et al. · Nature Cell Biology · 2012 · 915 citations · Full text

, , +16

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Dimitrios Anastasiou, Yimin Yu, William J. Israelsen et al. · Nature Chemical Biology · 2012 · 825 citations · Full text

, , +15