Theranostics · 2021 · 24 citations · 23 references
Life SciencesBiotechnologyOncologyGene TherapyGenome EditingNanobiotechnologyCancer BiotechnologyCancer NanomedicineCrispr-based EngineeringCrispr-cas SystemsNanomedicineTherapeutic Genome EditingCancer Gene EditingCrispr InterferenceCrispr-cas Genome EditingCrispr-cas TherapeuticsCrispr-cas9 Genome EditingIn Vivo Genome EditingInterferenceTumor Microenvironment Responsiveness
Taken together, these characteristics allow PICASSO to unleash the potential of CRISPR/dCas9-based therapeutics in oncological treatment. The study provides a simple and versatile strategy to break through the restriction of sizes and types against cancer by utilization of tumor endogenous gene.
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