Journal of Medicinal Chemistry · 2021 · 69 citations · 27 references
PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryLead OptimizationEnzyme InhibitionLead Compound DesignProtozoal InfectionsAntileishmanial TreatmentIn Vivo Efficacy TestingLead Compound OptimizationLeishmaniasis PathogenesisMode Of Action StudiesPolyadenylationPolyadenylation Factor FunctionTreatment Of Leishmaniasis
cleavage and polyadenylation specificity factor (CPSF3) endonuclease. As a result of these studies and its promising profile, DNDI-6148 has been declared a preclinical candidate for the treatment of VL.
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